王泉博

王泉博，男，南京大学化学博士，任山东省分析测试中心环境与健康免疫研究室、齐鲁工业大学（山东省科学院）药学院免疫药理中心副主任，工程师。已发表SCI论文50余篇，被引频次2400余次，单篇最高被引270余次，H指数25。主持国家及省自然科学基金项目等项目。

2017年起担任澳大利亚科学院院士Charles Mackay团队中方负责人，负责Mackay院士引进、研发团队组建、项目实施及成果转化等工作，协助Mackay院士开展其首创的“营养-肠道菌群-生理机能轴”理论防治免疫及代谢性疾病的机制研究及功能性医药产品研发，获批校（院）外经费支持逾2000万元。2021年基于与Mackay院士的联合研发成果“预防和治疗免疫代谢疾病的功能性淀粉产业化项目”创建山东善维免疫科技有限公司。

研究领域 ：

主要从事肠道免疫稳态调节机制研究及相关技术、功能性产品研发，用化学理论、方法和技术解决生物医学问题。

招生信息：

招收药学（专业学位）、化学（学术学位）学科研究生。

2011-2015，南京大学，博士

2008-2011，山东大学，硕士

2004-2008，山东大学，学士

代表性论文：

15. Gong, Q.; Wang, B.; Guo, M.; Zhao, Y.; Qu, X.; Ma, C.; Zhang, X.; Cao, S.; Mackay, C. R.; Song, Y.*; Wang, S.*; Wang, Q.*, Synthesis, in vivo colon-targeted delivery effect and gut microbiota modulation of indole-acetylated starches derived from various native starch structures. Carbohydrate Polymers 2025, 367, 124031.

14. Li, Y.; Zhang, Q.; Duan, B.; Qu, X.; Guo, M.; Mackay, C. R.; Zhang, X.*; Wang, Q.*, Near-infrared light driven photodynamic therapy by hyaluronic acid encapsulated ionic polymer integrated with oxygen self-supply and high acetate supplement for chronic wound healing. International Journal of Biological Macromolecules 2025, 314, 144424.

13. Gong, Q.; Qu, X.; Zhao, Y.; Zhang, X.; Cao, S.; Wang, X.; Song, Y.*; Mackay, C. R.*; Wang, Q.*, Indole-3-Acetic Acid Esterified with Waxy, Normal, and High-Amylose Maize Starches: Comparative Study on Colon-Targeted Delivery and Intestinal Health Impact. Nutrients 2024, 16, 3446.

12. Qu, X.; Song, Y.; Li, Q.; Xu, Q.; Li, Y.; Zhang, H.; Cheng, X.; Mackay, C. R.; Wang, Q.*; Liu, W.*, Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway. Archives of Pharmacal Research 2024, 47, 288-299.

11. Wang, Q.; Mackay, C. R.*, High metabolite concentrations in portal venous blood as a possible mechanism for microbiota effects on the immune system and Western diseases. Journal of Allergy and Clinical Immunology 2024, 153, 980-982.

10. Han, Y.; Qu, X.; Geng, H.; Wang, L.; Zhu, Z.; Zhang, Y.; Cui, X.; Lu, H.; Wang, X.; Chen, P.*; Wang, Q.*; Sun, C.*, Isotope-Coded On-Tissue Derivatization for Quantitative Mass Spectrometry Imaging of Short-Chain Fatty Acids in Biological Tissues. Analytical Chemistry 2023, 95, 17622-17628.

9. Li, Y.; Wang, Q.*; Qu, X.; Tian, J.; Zhang, X.*, Construction of palladium porphyrins and triptycene photo-activated nanomaterial for enhanced colorimetric detection and inactivation of bacteria. Journal of Colloid and Interface Science 2023, 648, 220-230.

8. Song, Y.; Qu, X.; Guo, M.; Hu, Q.; Mu, Y.; Hao, N.; Wei, Y.; Wang, Q.*; Mackay, C. R.*, Indole acetylated high-amylose maize starch: Synthesis, characterization and application for amelioration of colitis. Carbohydrate Polymers 2023, 302, 120425.

7. Xu, Q.; Zhang, R.; Mu, Y.; Song, Y.; Hao, N.; Wei, Y.; Wang, Q.*; Mackay, C. R.*, Propionate Ameliorates Alcohol-Induced Liver Injury in Mice via the Gut–Liver Axis: Focus on the Improvement of Intestinal Permeability. Journal of Agricultural and Food Chemistry 2022, 70, 6084-6096.

6. He, Y.; Fu, L.; Li, Y.; Wang, W.; Gong, M.; Zhang, J.; Dong, X.; Huang, J.; Wang, Q.; Mackay, C. R.; Fu, Y.-X.; Chen, Y.; Guo, X.*, Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metabolism 2021, 33, 988-1000.e7.

5. Cui, C.; Wang, Q. B.*; Xin, C. H.; Liu, Q. Y.; Deng, X.; Liu, T. T.; Xu, X. H.; Zhang, X. M.*, Covalent organic framework with bidentate ligand sites as reliable fluorescent sensor for Cu²⁺. Microporous and Mesoporous Materials 2020, 299, 110122.

4. Wang, Q. B.; Xu, N.; Lei, J. P.; Ju, H. X.*, Regulative peroxidase activity of DNA-linked hemin by graphene oxide for fluorescence DNA sensing. Chemical Communications 2014, 50, 6714-6717.

3. Wang, Q. B.; Wang, W.; Lei, J. P.; Xu, N.; Gao, F. L.; Ju, H. X.*, Fluorescence Quenching of Carbon Nitride Nanosheet through Its Interaction with DNA for Versatile Fluorescence Sensing. Analytical Chemistry 2013, 85, 12182-12188.

2. Wang, Q. B.; Lei, J. P.*; Deng, S. Y.; Zhang, L.; Ju, H. X.*, Graphene-supported ferric porphyrin as a peroxidase mimic for electrochemical DNA biosensing. Chemical Communications 2013, 49, 916-918.

1. Wang, Q. B.; Chen, Y. L.; Ma, P.; Lu, J. T.; Zhang, X. M.*; Jiang, J. Z.*, Morphology and chirality controlled self-assembled nanostructures of porphyrin-pentapeptide conjugate: effect of the peptide secondary conformation. Journal of Materials Chemistry 2011, 21, 8057-8065.