孙成龙

孙成龙，教授，博士生导师，山东省泰山学者青年专家。2015年硕士毕业于中国药科大学，2018年博士毕业于北京协和医学院，齐鲁工业大学（山东省科学院）药物代谢与分子成像团队PI。从事质谱成像和空间组学技术开发、药物和疾病代谢研究。主持国家自然科学基金2项，以第一或通讯作者（含共同）在Nature、Nat. Commun.、PNAS、 Adv. Sci.、Anal. Chem. 等期刊发表学术论文30余篇，以第一发明人授权国家发明专利5项，获中国分析测试协会科学技术奖特等奖、分析测试青年创新大赛一等奖，担任《分析仪器》编委、J. Pharm. Anal.、《分析测试学报》青年编委。

代表性论文：

1. Chen, P.^#, Geng, H.^#, Ma, B.^#, Zhang, Y., Zhu, Z., Li, M., Chen, S., Wang, X., and Sun, C.* Integrating spatial omics and single-cell mass spectrometry imaging reveals tumor-host metabolic interplay in hepatocellular carcinoma. PNAS, 2025, 122, e2505789122. (独立通讯)

2. Sun, C.^#, Wang, A.^#, Zhou, Y.^#, Chen, P., Wang, X., Huang, J., Gao, J., Wang, X., Shu, L., Lu, J., Dai, W.*, Bu, Z.*, Ji, J.*, and He, J.* Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer. Nat. Commun., 2023, 14, 2692. (第一作者)

3. Wang, N.^#, Chen, Z.^#, Yao, Y.^#, Sun, C.^#, Wei, W.^#, Sun, L.^#, Zhang, H.^#, Li, F.^#, Butcher, D., Sun, S.-R., Gong, J., Jiang, Y. C., Qi, Y., Huang, J., Nettelfield, S., Liu, R., Zheng, X., Li, C., Fu, Y., Geng, H., Zhao, L., Sun, H., Yang, Y., Ge, Y., Pazhouhandeh, M., Barlow, C. K., Jeppe, K. J., Yunis, J., Zhu, C., Wei, Y., Liang, X., Bridle, K., Frazer, D. M., Tey, S.-K., Li, Y., Yang, Z., Shu, M., Liu, Z., Crawford, D., and Yu, D.* Lipid metabolism drives dietary effects on T cell ferroptosis and immunity. Nature, 2026, 653, 200-211. (共同第一作者)

4. Sun, C., Li, T., Song, X., Huang, L., Zang, Q., Xu, J., Bi, N., Jiao, G., Hao, Y., Chen, Y., Zhang, R., Luo, Z., Li, X., Wang, L., Wang, Z., Song, Y., He, J.*, and Abliz, Z.* Spatially resolved metabolomics to discover tumor-associated metabolic alterations. PNAS, 2019, 116, 52-57. (第一作者)

5. Chen, S.^#, Lv, C.^#, Li, Z., Ma, B., Ma, J., Li, M., Zhang, X., Li, M., Zhao, H., Liu, W., Li, Y., Wang, X., Chen, P.*, and Sun, C.* Integrating mass spectrometry imaging with tumor organoid-immunity platform to identify metabolic adaptations in tumor immune resistance. Anal. Chem., 2026, 98, 20039-20048. (最后通讯)

6. Zhang, Y.^#, Chen, P.^#, Geng, H., Li, M., Chen, S., Ma, B., Ma, Y., Lai, J., Cui, X., Chong, W., Chen, H., Wang, X., and Sun, C.* Development of a single-cell spatial metabolomics method for the characterization of cell-cell metabolic interactions. Anal. Chem., 2025, 97, 7986-7994. (独立通讯)

7. Cui, X., Chen, S., Geng, H., Chen, P., Zhang, Y., Li, M., Wang, X., and Sun, C.* Integrating thiolated mass tags with immuno-mass spectrometry imaging to map the spatial signatures of functional proteins in cancer tissues. Anal. Chem., 2025, 97, 18460-18468. (独立通讯)

8. Geng, H.^#, Chen, P.^#, Zhang, Y., Zhu, Z., Zhao, Y., Wang, X., and Sun, C.* Spatiotemporally resolved approach for profiling ferroptosis-associated metabolic vulnerabilities in tumors using mass spectrometry imaging and stable isotope tracing. Anal. Chem., 2024, 96, 20039-20048. (独立通讯)

9. Chen, P., Han, Y., Wang, L., Zheng, Y., Zhu, Z., Zhao, Y., Zhang, M., Chen, X., Wang, X., and Sun, C.* Spatially resolved metabolomics combined with the 3D tumor-immune cell coculture spheroid highlights metabolic alterations during antitumor immune response. Anal. Chem., 2023, 95, 15153-15161. (独立通讯)

10. Han, Y.^#, Qu, X.^#, Geng, H., Wang, L., Zhu, Z., Zhang, Y., Cui, X., Lu, H., Wang, X., Chen, P.*, Wang, Q.*, and Sun, C.* Isotope-coded on-tissue derivatization for quantitative mass spectrometry imaging of short-chain fatty acids in biological tissues. Anal. Chem., 2023, 95, 17622-17628. (最后通讯)

11. Sun, C.*, Liu, W., Geng, Y., and Wang, X.* On-tissue derivatization strategy for mass spectrometry imaging of carboxyl-containing metabolites in biological tissues. Anal. Chem., 2020, 92, 12126-12131. (第一作者、共同通讯)

2007.09~2012.07，山东第一医科大学，药学院，药学（临床药学方向，五年制），大学本科

2012.09~2015.07，中国药科大学，药学院，药物分析学，硕士研究生

2015.09~2018.07，北京协和医学院，药物研究所，药物分析学，博士研究生

2018.08~至今，山东省分析测试中心，药学院，齐鲁工业大学（山东省科学院）

博士：材料与化工（专业学位）

硕士：药学（专业学位）、化学（学术学位）